芯片上器官
微流控
药物开发
计算机科学
神经科学
药品
纳米技术
医学
生物
药理学
材料科学
作者
Behnam Noorani,Luca Cucullo,Yeseul Ahn,Hossam Kadry,Aditya Bhalerao,Snehal Raut,Ehsan Nozohouri,Ekram Ahmed Chowdhury
出处
期刊:Current Neuropharmacology
[Bentham Science]
日期:2023-03-01
卷期号:21 (3): 599-620
标识
DOI:10.2174/1570159x20666220706112711
摘要
Abstract: The vascular system plays a critical role in human physiology and diseases. It is a complex subject to study using in vitro models due to its dynamic and three-dimensional microenvironment. Microfluidic technology has recently become a popular technology in various biological fields for its advantages in mimicking complex microenvironments to an extent not achievable by more conventional platforms. Microfluidic technologies can reproduce different vascular system-related structures and functions that can be utilized for drug development and human diseases studies. Herein we first review the relevant structural and functional vascular biology systems of various organ systems and then the fabrication methods to reproduce these vascular districts. We provide a thorough review of the latest achievement in vascular organ-on-chip modeling specific to lung, heart, and the brain microvasculature for drug screening and the study of human disorders.
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