5-羟色胺能
神经科学
血清素
厌恶性刺激
生物
重编程
秀丽隐杆线虫
逃生响应
联想学习
5-羟色胺受体
心理学
作者
Yueh-Chen Chiang,Chien-Po Liao,Chun-Liang Pan
标识
DOI:10.1073/pnas.2115533119
摘要
SignificancePhysiological stress triggers avoidance behavior, allowing the animals to stay away from potential threats and optimize their chance of survival. Mitochondrial disruption, a common physiological stress in diverse species, induces the nematode Caenorhabditis elegans to avoid non-pathogenic bacteria through a serotonergic neuronal circuit. We find that distinct neurons, communicated through serotonin and a specific serotonin receptor, are required for the formation and retrieval of this learned aversive behavior. This learned avoidance behavior is associated with increased serotonin synthesis, altered neuronal response property, and reprogramming of locomotion patterns. The circuit and neuromodulatory mechanisms described here offer important insights for stress-induced avoidance behavior.
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