止血
壳聚糖
伤口愈合
材料科学
止血剂
生物医学工程
石墨烯
血小板
生物医学中的光声成像
纳米技术
体内
医学
外科
化学
内科学
光学
生物技术
物理
生物
生物化学
作者
Xiangwei Lin,Yajing Shen,Lidai Wang
出处
期刊:Nanomaterials
[MDPI AG]
日期:2021-10-28
卷期号:11 (11): 2879-2879
被引量:5
摘要
Hemostasis is vital to save lives, reducing risks of organ failure and hemorrhagic shock. Exploring novel hemostatic materials and precise monitoring of the hemostatic status is of great importance for efficient hemostasis. We present the development of chitosan-graphene oxide-based hemostatic composite and multi-scale photoacoustic evaluation of the hemostatic performance. The hemostatic sponge can quickly and efficiently absorb the blood with its porous cavity and specific surficial property. We inspect the hemostatic performance via an in vitro blood absorption test and in vivo mouse bleeding injury experiments. Results show that the synthesized hemostatic sponge can not only absorb plasma in blood fast with its interior porous structure but also stimulate the interfacial reaction with erythrocytes and platelets. The superiority of multi-scale photoacoustic imaging for guiding, monitoring, and evaluating the hemostatic stages of sponges is demonstrated with high spatial resolution and great sensitivity at depths. Photoacoustic evaluation of a chitosan-graphene oxide-based hemostatic sponge has the potential to be transferred toward the clinical assessment of wound healing.
科研通智能强力驱动
Strongly Powered by AbleSci AI