伤口愈合
血管生成
成纤维细胞生长因子
体内
外体
止血
自愈水凝胶
药理学
生长因子
微泡
成纤维细胞
医学
慢性伤口
癌症研究
化学
体外
外科
生物
内科学
受体
生物化学
小RNA
有机化学
生物技术
基因
作者
Yuan Xiong,Lang Chen,Pei Liu,Tao Yu,Changjian Lin,Chenchen Yan,Yiqiang Hu,Wu Zhou,Yun Sun,Adriana C. Panayi,Faqi Cao,Hang Xue,Liangcong Hu,Ze Lin,Xudong Xie,Xiufeng Xiao,Feng Qian,Bobin Mi,Guohui Liu
出处
期刊:Small
[Wiley]
日期:2021-11-17
卷期号:18 (1)
被引量:146
标识
DOI:10.1002/smll.202104229
摘要
The treatment of diabetic wounds remains a major challenge in clinical practice, with chronic wounds characterized by multiple drug-resistant bacterial infections, angiopathy, and oxidative damage to the microenvironment. Herein, a novel in situ injectable HA@MnO2 /FGF-2/Exos hydrogel is introduced for improving diabetic wound healing. Through a simple local injection, this hydrogel is able to form a protective barrier covering the wound, providing rapid hemostasis and long-term antibacterial protection. The MnO2 /ε-PL nanosheet is able to catalyze the excess H2 O2 produced in the wound, converting it to O2 , thus not only eliminating the harmful effects of H2 O2 but also providing O2 for wound healing. Moreover, the release of M2-derived Exosomes (M2 Exos) and FGF-2 growth factor stimulates angiogenesis and epithelization, respectively. These in vivo and in vitro results demonstrate accelerated healing of diabetic wounds with the use of the HA@MnO2 /FGF-2/Exos hydrogel, presenting a viable strategy for chronic diabetic wound repair.
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