梭菌纲
生物
抗毒素
微生物学
暴发型
毒素
毒力
微生物毒素
造孔毒素
艰难梭菌
结肠炎
艰难梭菌毒素A
免疫学
抗生素
基因
生物化学
作者
Shannon Lynn Kordus,Audrey K. Thomas,D. Borden Lacy
标识
DOI:10.1038/s41579-021-00660-2
摘要
Clostridioides difficile is a Gram-positive anaerobe that can cause a spectrum of disorders that range in severity from mild diarrhoea to fulminant colitis and/or death. The bacterium produces up to three toxins, which are considered the major virulence factors in C. difficile infection. These toxins promote inflammation, tissue damage and diarrhoea. In this Review, we highlight recent biochemical and structural advances in our understanding of the mechanisms that govern host-toxin interactions. Understanding how C. difficile toxins affect the host forms a foundation for developing novel strategies for treatment and prevention of C. difficile infection.
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