STRUCTURE-ACTIVITY INVESTIGATION OF ATYPICAL ACRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS

Although acridines and many tricylic compounds are known to possess potent antimicrobial activity, yet most of these compounds are either toxic (cannot be used systemically) or have other pharmacological activities. To develop safe and effective agents, we report the design and synthesis of nonclassical acridine derivatives. Biological evaluation of these acridine analogues showed a consistent structure-activity relationship. Some of these acridines showed potent antimicrobial activity, compound 22 exhibited MIC of 7 ug / mL.