氧化还原
介孔材料
介孔二氧化硅
化学工程
毒品携带者
材料科学
药品
纳米技术
化学
无机化学
药物输送
有机化学
药理学
催化作用
医学
工程类
作者
Mengru Chen,Yunyun Chen,Yanbao Zhao,Xueyan Zou,Lei Sun
标识
DOI:10.1016/j.jddst.2021.102763
摘要
In this work, we prepared three kinds of mesoporous silica (MS) nanoparticles (NPs) with different aspect ratio. These samples are uniform spheres (MS1) with diameter of 100 nm and nanorods (MS2 and MS3) with same diameter, and the corresponding aspect ratio was 1, 2 and 3, respectively. The as-prepared MS samples presented aspect ratio-dependent specific surface area, cell uptake rate and drug loading capacity. The MS3 sample showed higher cell uptake rate and specific surface area (984 m 2 g -1 ), which was used as carrier to construct drug delivery system. Doxorubicin (Dox) is used as model drug to evaluate the release performance of MS3 carriers. After loading Dox, ceria (CeO 2 ) NPs were capped on the surface of MS3 carriers to block the loaded-drug. Due to the dissolution of CeO 2 in acidic or reducing environment, the MS3/CeO 2 system displayed redox/pH-responsive and sustained release behavior. Mesoporous silica nanorods were prepared for redox/pH responsive drug release.
科研通智能强力驱动
Strongly Powered by AbleSci AI