生物
免疫系统
微生物学
肠道菌群
抗原
效应器
病菌
粘膜免疫学
共生
免疫
免疫学
细菌
遗传学
作者
Daniel F. Zegarra-Ruiz,Dasom V. Kim,Kendra Norwood,Myunghoo Kim,Wan Jung H. Wu,Fatima B. Saldana-Morales,Andrea A. Hill,Shubhabrata Majumdar,Stephanie Orozco,Rickesha Bell,June L. Round,Randy S. Longman,Takeshi Egawa,Matthew L. Bettini,Gretchen E. Diehl
出处
期刊:Nature
[Springer Nature]
日期:2021-05-12
卷期号:594 (7863): 413-417
被引量:103
标识
DOI:10.1038/s41586-021-03531-1
摘要
Humans and their microbiota have coevolved a mutually beneficial relationship in which the human host provides a hospitable environment for the microorganisms and the microbiota provides many advantages for the host, including nutritional benefits and protection from pathogen infection1. Maintaining this relationship requires a careful immune balance to contain commensal microorganisms within the lumen while limiting inflammatory anti-commensal responses1,2. Antigen-specific recognition of intestinal microorganisms by T cells has previously been described3,4. Although the local environment shapes the differentiation of effector cells3–5 it is unclear how microbiota-specific T cells are educated in the thymus. Here we show that intestinal colonization in early life leads to the trafficking of microbial antigens from the intestine to the thymus by intestinal dendritic cells, which then induce the expansion of microbiota-specific T cells. Once in the periphery, microbiota-specific T cells have pathogenic potential or can protect against related pathogens. In this way, the developing microbiota shapes and expands the thymic and peripheral T cell repertoire, allowing for enhanced recognition of intestinal microorganisms and pathogens. In young mice, antigens from the gut microbiota are trafficked by CX3CR1+ dendritic cells from the gut to the thymus, where they induce the expansion of T cells that are specific to commensal microorganisms.
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