立体选择性
重氮
化学
卡宾
亲核细胞
催化作用
联轴节(管道)
偶联反应
组合化学
有机化学
机械工程
工程类
出处
期刊:Organic Letters
[American Chemical Society]
日期:2017-06-13
卷期号:19 (13): 3482-3485
被引量:46
标识
DOI:10.1021/acs.orglett.7b01467
摘要
A stereoselective, gold-catalyzed, cross-coupling reaction of enynones with diazo compounds has been developed, affording 2-alkenylfurans in moderate to good yields with excellent E-stereoselectivity. Upon using diazo compounds as nucleophiles to trap the in situ formed gold furyl carbene, this protocol provides a novel path toward the formation of unsymmetrical tetrasubstituted alkenes.
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