短梗霉
苹果酸
发酵
食品科学
生物量(生态学)
化学
生物反应器
蔗糖
水解
制浆造纸工业
生物技术
生物化学
生物
有机化学
农学
柠檬酸
工程类
作者
Peilian Wei,Chi Cheng,Lin Meng,Yunfeng Zhou,Shang‐Tian Yang
标识
DOI:10.1016/j.biortech.2016.11.003
摘要
Poly(β-l-malic acid) (PMA) is a biodegradable polymer with many potential biomedical applications. PMA can be readily hydrolyzed to malic acid (MA), which is widely used as an acidulant in foods and pharmaceuticals. PMA production from sucrose and sugarcane juice by Aureobasidium pullulans ZX-10 was studied in shake-flasks and bioreactors, confirming that sugarcane juice can be used as an economical substrate without any pretreatment or nutrients supplementation. A high PMA titer of 116.3g/L and yield of 0.41g/g were achieved in fed-batch fermentation. A high productivity of 0.66g/L·h was achieved in repeated-batch fermentation with cell recycle. These results compared favorably with those obtained from glucose and other biomass feedstocks. A process economic analysis showed that PMA could be produced from sugarcane juice at a cost of $1.33/kg, offering a cost-competitive bio-based PMA for industrial applications.
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