医学
转染
免疫学
癌症
阶段(地层学)
过继性细胞移植
癌症研究
免疫系统
生物
细胞培养
内科学
T细胞
遗传学
古生物学
作者
Li Hua,Mingli Fang,Boqi Dong,Sheng Guo,Cuiyun Cui,Ji-Wei Liu,Yun Chiao Yao,Yue Xiao,Xin Li,Yunjia Ren,Xiuping Meng,Xu Hao,Peiyan Zhao,Yilan Song,Liying Wang,Yongli Yu
出处
期刊:Oncotarget
[Impact Journals, LLC]
日期:2016-07-19
卷期号:7 (50): 82369-82383
被引量:1
标识
DOI:10.18632/oncotarget.10693
摘要
Allogeneic tumors are eventually rejected by adaptive immune responses, however, little is known about how allogeneic tumors are eradicated at the early stage of tumor development. In present study, we found that NKG2DL low expressing cancer cells were developed into palpable allogeneic tumors in mice within a week after the inoculation, while NKG2DL high expressing cancer cells failed to. The NKG2DL high expressing cancer cells could increase NKG2D+ NK cells in the allogeneic mice after being inoculated for 3 days. Artificially up-regulating NKG2DL on cancer cells with low level expressed NKG2DL by a CpG ODN resulted in the retardation and rejection of the allogeneic tumors at the early stage. The contribution of up-regulated NKG2DL to the early rejection was further confirmed by the results that the development of allogeneic tumors from cancer cells transfected with NKG2DL genes was significantly inhibited in mice at the early stage. Overall, hopefully, the data may provide insights for combining the allogeneic NK cell adoptive transfer with the approaches of up-regulating NKG2DL to treat cancer patients.
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