线粒体
细胞生物学
程序性细胞死亡
细胞器
细胞代谢
细胞内
活性氧
细胞凋亡
生物
细胞代谢
新陈代谢
细胞
化学
生物化学
作者
Helin Vakifahmetoglu-Norberg,Amanda Tomie Ouchida,Erik Norberg
标识
DOI:10.1016/j.bbrc.2016.11.088
摘要
Mitochondria are complex organelles that play a central role in energy metabolism, control of stress responses and are a hub for biosynthetic processes. Beyond its well-established role in cellular energetics, mitochondria are critical mediators of signals to propagate various cellular outcomes. In addition mitochondria are the primary source of intracellular reactive oxygen species (ROS) generation and are involved in cellular Ca2+ homeostasis, they contain a self-destructive arsenal of apoptogenic factors that can be unleashed to promote cell death, thus displaying a shared platform for metabolism and apoptosis. In the present review, we will give a brief account on the integration of mitochondrial metabolism and apoptotic cell death.
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