格兰杰因果关系
连接体
电生理学
神经科学
因果关系(物理学)
计算机科学
心理学
物理
功能连接
机器学习
量子力学
作者
Abbas Sohrabpour,Shuai Ye,Gregory A. Worrell,Wenbo Zhang,Bin He
出处
期刊:IEEE Transactions on Biomedical Engineering
[Institute of Electrical and Electronics Engineers]
日期:2016-12-01
卷期号:63 (12): 2474-2487
被引量:45
标识
DOI:10.1109/tbme.2016.2616474
摘要
Combined source-imaging techniques and directional connectivity analysis can provide useful information about the underlying brain networks in a noninvasive fashion. Source-imaging techniques have been used successfully to either determine the source of activity or to extract source time-courses for Granger causality analysis, previously. In this work, we utilize source-imaging algorithms to both find the network nodes [regions of interest (ROI)] and then extract the activation time series for further Granger causality analysis. The aim of this work is to find network nodes objectively from noninvasive electromagnetic signals, extract activation time-courses, and apply Granger analysis on the extracted series to study brain networks under realistic conditions.Source-imaging methods are used to identify network nodes and extract time-courses and then Granger causality analysis is applied to delineate the directional functional connectivity of underlying brain networks. Computer simulations studies where the underlying network (nodes and connectivity pattern) is known were performed; additionally, this approach has been evaluated in partial epilepsy patients to study epilepsy networks from interictal and ictal signals recorded by EEG and/or Magnetoencephalography (MEG).Localization errors of network nodes are less than 5 mm and normalized connectivity errors of ∼20% in estimating underlying brain networks in simulation studies. Additionally, two focal epilepsy patients were studied and the identified nodes driving the epileptic network were concordant with clinical findings from intracranial recordings or surgical resection.Our study indicates that combined source-imaging algorithms with Granger causality analysis can identify underlying networks precisely (both in terms of network nodes location and internodal connectivity).The combined source imaging and Granger analysis technique is an effective tool for studying normal or pathological brain conditions.
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