生物
转录因子
NF-κB
基因
NFKB1型
遗传学
免疫系统
计算生物学
抄写(语言学)
基因表达调控
信号转导
语言学
哲学
作者
Qian Zhang,Michael J. Lenardo,David Baltimore
出处
期刊:Cell
[Elsevier]
日期:2017-01-01
卷期号:168 (1-2): 37-57
被引量:1425
标识
DOI:10.1016/j.cell.2016.12.012
摘要
NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that time, it has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system. Here, we summarize elaborate regulatory pathways involving this transcription factor and use recent discoveries in human genetic diseases to place specific proteins within their relevant medical and biological contexts.
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