阈下刺激
催产素
心理学
扁桃形结构
扣带回前部
额下回
脑岛
焦虑
面部表情
社交焦虑
背景(考古学)
神经科学
感觉加工
功能磁共振成像
发展心理学
听力学
认知
医学
认知心理学
感觉系统
精神科
沟通
生物
古生物学
作者
Li Luo,Benjamin Becker,Yayuan Geng,Zhiying Zhao,Shan Gao,Weihua Zhao,Shuxia Yao,Xiaoxiao Zheng,Xiaole Ma,Zhao Gao,Jiehui Hu,Keith M. Kendrick
出处
期刊:NeuroImage
[Elsevier]
日期:2017-11-01
卷期号:162: 127-137
被引量:81
标识
DOI:10.1016/j.neuroimage.2017.08.079
摘要
In line with animal models indicating sexually dimorphic effects of oxytocin (OXT) on social-emotional processing, a growing number of OXT-administration studies in humans have also reported sex-dependent effects during social information processing. To explore whether sex-dependent effects already occur during early, subliminal, processing stages the present pharmacological fMRI-study combined the intranasal-application of either OXT or placebo (n = 86–43 males) with a backward-masking emotional face paradigm. Results showed that while OXT suppressed inferior frontal gyrus, dorsal anterior cingulate and anterior insula responses to threatening face stimuli in men it increased them in women. In women increased anterior cingulate reactivity during subliminal threat processing was also positively associated with trait anxiety. On the network level, sex-dependent effects were observed on amygdala, anterior cingulate and inferior frontal gyrus functional connectivity that were mainly driven by reduced coupling in women following OXT. Our findings demonstrate that OXT produces sex-dependent effects even at the early stages of social-emotional processing, and suggest that while it attenuates neural responses to threatening social stimuli in men it increases them in women. Thus in a therapeutic context OXT may potentially produce different effects on anxiety disorders in men and women.
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