医学
生物标志物
创伤性脑损伤
神经科学
癫痫
外围设备
血脑屏障
脑功能
中枢神经系统
外周血
生物标志物发现
生物信息学
内科学
蛋白质组学
精神科
化学
基因
生物
生物化学
作者
Natalia Chmielewska,Janusz Szyndler,Karolina Makowska,Dawid Wojtyna,Piotr Maciejak,Adam Płaźnik
出处
期刊:Neurologia I Neurochirurgia Polska
[VM Media Sp zo.o. - VMGroup SK]
日期:2018-05-01
卷期号:52 (3): 318-325
被引量:33
标识
DOI:10.1016/j.pjnns.2018.02.002
摘要
The role of blood brain barrier (BBB) is to preserve a precisely regulated environment for proper neuronal signaling. In many of the central nervous system (CNS) pathologies, the function of BBB is altered. Thus, there is a necessity to evaluate a fast, noninvasive and reliable method for monitoring of BBB condition. It seems that revealing the peripheral diagnostic biomarker whose release pattern (concentration, dynamics) will be correlated with clinical symptoms of neurological disorders offers significant hope. It could help with faster diagnosis and efficient treatment monitoring. In this review we summarize the recent data concerning exploration of potential new serum biomarkers appearing in the peripheral circulation following BBB disintegration, with an emphasis on epilepsy, traumatic brain injury (TBI) and stroke. We consider the application of well-known proteins (S100β and GFAP) as serum indicators in the light of recently obtained results. Furthermore, the utility of molecules like MMP-9, UCHL-1, neurofilaments, BDNF, and miRNA, which are newly recognized as a potential serum biomarkers, will also be discussed.
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