Dissecting Intracellular Proteolysis Using Small Molecule Inhibitors and Molecular Probes

This chapter contains sections titled: Introduction The Proteasome as an Essential Component of Intracellular Proteolysis Proteasome Structure, Function, and Localization Proteasome Inhibitors as Tools to Study Proteasome Function Peptide Aldehydes Lactacystin Peptide Epoxyketones Cyclic Peptides Peptide Boronates Peptide Vinyl Sulfones Peptide Vinyl Sulfones as Proteasomal Activity Probes Future Directions in the Development of Inhibitors of the Proteasome's Proteolytic Activities Assessing the Biological Role of the Proteasome With Inhibitors and Probes Proteasome-associated Components: The Role of N-glycanase A Link Between Proteasomal Proteolysis and Deubiquitination Reversal of Ub Modification Ubiquitin-specific Proteases USP Reactive Probes Correlate USP Activity With Proteasomal Proteolysis Future Developments and Final Remarks Acknowledgments Abbreviations References