内部收益率3
核酸
干扰素
干扰素调节因子
生物
Ⅰ型干扰素
核糖核酸
DNA
分子生物学
生物化学
转录因子
化学
细胞生物学
病毒学
基因
作者
Pengyuan Yang,Huazhang An,Xingguang Liu,Mingyue Wen,Yuanyuan Zheng,Yao-Cheng Rui,Xuetao Cao
摘要
Intracellular nucleic acid sensors detect microbial RNA and DNA and trigger the production of type I interferon. However, the cytosolic nucleic acid-sensing system remains to be fully identified. Here we show that the cytosolic nucleic acid-binding protein LRRFIP1 contributed to the production of interferon-beta (IFN-beta) induced by vesicular stomatitis virus (VSV) and Listeria monocytogenes in macrophages. LRRFIP1 bound exogenous nucleic acids and increased the expression of IFN-beta induced by both double-stranded RNA and double-stranded DNA. LRRFIP1 interacted with beta-catenin and promoted the activation of beta-catenin, which increased IFN-beta expression by binding to the C-terminal domain of the transcription factor IRF3 and recruiting the acetyltransferase p300 to the IFN-beta enhanceosome via IRF3. Therefore, LRRFIP1 and its downstream partner beta-catenin constitute another coactivator pathway for IRF3-mediated production of type I interferon.
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