医学
比例危险模型
转移
内科学
危险系数
外科
肿瘤科
癌症
随机对照试验
存活率
胃肠病学
置信区间
作者
Kazuo Hirose,Kanji Katayama,Atsuo Iida,Akio Yamaguchi,Gizo Nakagawara,Syun-ichi Umeda,Yukinori Kusaka
出处
期刊:Oncology
[S. Karger AG]
日期:1999-01-01
卷期号:57 (2): 106-114
被引量:92
摘要
Thirty-two patients with advanced gastric cancer underwent continuous hyperthermic peritoneal perfusion (CHPP) combined with surgery: to prevent peritoneal recurrence in 15 patients without peritoneal metastasis (prophylactic CHPP) and to treat 17 patients with peritoneal metastases (therapeutic CHPP). The postoperative outcome was compared with that of control patients treated with surgery alone. Peritoneal recurrence was less frequent (26%) and the 5-year survival rate was significantly higher (39%) in the patients with prophylactic CHPP than in 40 control patients (42 and 17%, respectively). The patients with therapeutic CHPP showed significantly better median survival than did 20 control patients (11 vs. 6 months). Cox multivariate regression analysis revealed that CHPP was an independent prognostic factor in the prophylactic study (hazard ratio = 0.3965), and that the independent prognostic factor in the therapeutic study was not CHPP but complete resection of the peritoneal metastasis. Thus, CHPP has no marked benefit for established peritoneal metastasis. CHPP for the prevention of peritoneal recurrence may have a beneficial effect on long-term survival, but a prospective randomized trial is needed to clarify its prognostic value.
科研通智能强力驱动
Strongly Powered by AbleSci AI