环加成
化学
分子内力
炔烃
组合化学
细胞凋亡
催化作用
立体化学
有机化学
生物化学
作者
Norman Nicolaus,Susanne Strauss,Jörg‐Martin Neudörfl,Aram Prokop,Hans‐Günther Schmalz
出处
期刊:Organic Letters
[American Chemical Society]
日期:2008-12-18
卷期号:11 (2): 341-344
被引量:65
摘要
Following an A → ABC strategy, a new synthesis of 6-oxa-allocolchicinoids was developed exploiting a microwave-promoted Co- or Rh-catalyzed intramolecular [2 + 2 + 2]-cycloaddition (alkyne cyclotrimerization) as a key step. The approach opens a short and efficient access to a variety of novel compounds, some of which were found to exhibit significant and selective apoptosis-inducing activities against BJAB tumor cells.
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