视觉光转导
瞬时受体电位通道
跨膜蛋白
生物
跨膜结构域
果蝇科
基因座(遗传学)
细胞生物学
视紫红质
信号转导
突变体
黑腹果蝇
生物化学
基因
受体
视网膜
作者
Craig Montell,Gerald M. Rubin
出处
期刊:Neuron
[Elsevier]
日期:1989-04-01
卷期号:2 (4): 1313-1323
被引量:1025
标识
DOI:10.1016/0896-6273(89)90069-x
摘要
Recent studies suggest that the fly uses the inositol lipid signaling system for visual excitation and that the Drosophila transient receptor potential (trp) mutation disrupts this process subsequent to the production of IP3. In this paper, we show that trp encodes a novel 1275 amino acid protein with eight putative transmembrane segments. Immunolocalization indicates that the trp protein is expressed predominantly in the rhabdomeric membranes of the photoreceptor cells.
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