致密斑
管球反馈
肾素-血管紧张素系统
肾单位
球旁器
肾
限制
内分泌学
平衡
内科学
化学
旁分泌信号
入球微动脉
细胞生物学
生物
医学
血压
受体
工程类
机械工程
作者
János Peti-Peterdi,Raymond C. Harris
出处
期刊:Journal of The American Society of Nephrology
日期:2010-07-01
卷期号:21 (7): 1093-1096
被引量:137
标识
DOI:10.1681/asn.2009070759
摘要
Macula densa cells in the distal nephron, according to the classic paradigm, are salt sensors that generate paracrine chemical signals in the juxtaglomerular apparatus to control vital kidney functions, including renal blood flow, glomerular filtration, and renin release. Renin is the rate-limiting step in the activation of the renin-angiotensin system, a key modulator of body fluid homeostasis. Here, we discuss recent advances in understanding macula densa sensing and suggest these cells, in addition to salt, also sense various chemical and metabolic signals in the tubular environment that directly trigger renin release.
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