拟南芥
转录因子
生物
染色质免疫沉淀
细胞生物学
抄写(语言学)
染色质
调节器
乙烯
转录调控
基因
信号转导
响应调节器
基因表达调控
遗传学
基因表达
生物化学
发起人
突变体
哲学
催化作用
语言学
作者
Katherine Noelani Chang,Shan Zhong,Matthew T. Weirauch,Gary C. Hon,Mattia Pelizzola,Hai Li,S. Huang,Robert J. Schmitz,Mark A. Urich,Dwight Kuo,Joseph R. Nery,Hong Qiao,Ally Yang,Abdullah Jamali,Huaming Chen,Trey Ideker,Bing Ren,Ziv Bar‐Joseph,Timothy R. Hughes,Joseph R. Ecker
出处
期刊:eLife
[eLife Sciences Publications, Ltd.]
日期:2013-06-11
卷期号:2
被引量:344
摘要
The gaseous plant hormone ethylene regulates a multitude of growth and developmental processes. How the numerous growth control pathways are coordinated by the ethylene transcriptional response remains elusive. We characterized the dynamic ethylene transcriptional response by identifying targets of the master regulator of the ethylene signaling pathway, ETHYLENE INSENSITIVE3 (EIN3), using chromatin immunoprecipitation sequencing and transcript sequencing during a timecourse of ethylene treatment. Ethylene-induced transcription occurs in temporal waves regulated by EIN3, suggesting distinct layers of transcriptional control. EIN3 binding was found to modulate a multitude of downstream transcriptional cascades, including a major feedback regulatory circuitry of the ethylene signaling pathway, as well as integrating numerous connections between most of the hormone mediated growth response pathways. These findings provide direct evidence linking each of the major plant growth and development networks in novel ways.
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