血栓形成
组织工程
医学
外科
临床试验
生物医学工程
病理
血栓形成
作者
Yuji Naito,Toshiharu Shinoka,Daniel R. Duncan,Narutoshi Hibino,Daniel Solomon,Muriel A. Cleary,Animesh Rathore,Corey W. Fein,Spencer N. Church,Christopher K. Breuer
标识
DOI:10.1016/j.addr.2011.03.001
摘要
The application of tissue engineering technology to cardiovascular surgery holds great promise for improving outcomes in patients with cardiovascular diseases. Currently used synthetic vascular grafts have several limitations including thrombogenicity, increased risk of infection, and lack of growth potential. We have completed the first clinical trial evaluating the feasibility of using tissue engineered vascular grafts (TEVG) created by seeding autologous bone marrow-derived mononuclear cells (BM-MNC) onto biodegradable tubular scaffolds. Despite an excellent safety profile, data from the clinical trial suggest that the primary graft related complication of the TEVG is stenosis, affecting approximately 16% of grafts within the first seven years after implantation. Continued investigation into the cellular and molecular mechanisms underlying vascular neotissue formation will improve our basic understanding and provide insights that will enable the rationale design of second generation TEVG.
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