脉冲前抑制
习惯化
生物
门控
神经科学
惊吓反应
心理学
精神分裂症(面向对象编程)
精神科
作者
Nardos Lijam,Richard Paylor,Michael P. McDonald,Jacqueline N. Crawley,Chu Xia Deng,Karl Herrup,Karen E. Stevens,Gianmaria Maccaferri,Chris J. McBain,Daniel L. Sussman,Anthony Wynshaw‐Boris
出处
期刊:Cell
[Elsevier]
日期:1997-09-01
卷期号:90 (5): 895-905
被引量:444
标识
DOI:10.1016/s0092-8674(00)80354-2
摘要
Mice completely deficient for Dvl1, one of three mouse homologs of the Drosophila segment polarity gene Dishevelled, were created by gene targeting. Dvl1-deficient mice are viable, fertile, and structurally normal. Surprisingly, these mice exhibited reduced social interaction, including differences in whisker trimming, deficits in nest-building, less huddling contact during home cage sleeping, and subordinate responses in a social dominance test. Sensorimotor gating was abnormal, as measured by deficits in prepulse inhibition of acoustic and tactile startle. Thus, Dvl1 mutants may provide a model for aspects of several human psychiatric disorders. These results are consistent with an interpretation that common genetic mechanisms underlie abnormal social behavior and sensorimotor gating deficits and implicate Dvl1 in processes underlying complex behaviors.
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