环子孢子蛋白
恶性疟原虫
免疫原性
抗体
免疫印迹
病毒学
疟疾疫苗
重组DNA
生物
肽
疟疾
生物化学
免疫学
基因
作者
W. Ripley Ballou,Jonathan B. Rothbard,Robert A. Wirtz,Daniel M. Gordon,Jon H Sims Williams,R.W. Gore,Imogene Schneider,Michael R. Hollingdale,R. L. Beaudoin,W L Maloy
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1985-05-24
卷期号:228 (4702): 996-999
被引量:197
标识
DOI:10.1126/science.2988126
摘要
In a study of recombinant proteins that might be useful in developing a vaccine against malaria, synthetic peptides from the circumsporozoite (CS) protein of Plasmodium falciparum were found to be immunogenic for mice and rabbits. Antibody to peptides from the repeating region of the CS protein recognized native CS protein and blocked sporozoite invasion of human hepatoma cells in vitro. Antibodies to peptides from regions I and II had no biologic activity, although antibody to region I recognized processed CS protein by Western blot analysis. These data support the feasibility of developing a vaccine against the sporozoite stage of the malaria parasite by using synthetic peptides of the repeating region of the CS protein conjugated to a carrier protein.
科研通智能强力驱动
Strongly Powered by AbleSci AI