硫酚
化学
烷基化
吡啶
硫酸
烷基
产量(工程)
硼
有机化学
电泳剂
药物化学
亲电取代
催化作用
冶金
材料科学
作者
Deniz Z. Gunes,Okan Sírkecíoǧlu,Niyazi Bıçak
标识
DOI:10.1080/10426500903213563
摘要
A simple and convenient one-pot procedure is described for the synthesis of thioethers via boron esters. This procedure involves in-situ generation of alkyl sulfates by reaction of trialkyl borates with concentrated sulfuric acid and subsequent reaction with thiols in the presence of pyridine. The reactions with boron esters of primary or secondary alcohols proceed cleanly at 100°C and afford aliphatic thioethers in reasonable yields (59–93%) within 24 h. Interestingly, the 1H NMR spectra of the products showed no sign of positional isomerisms. The method fails however with thiophenol and does not yield aromatic thioethers, due to electrophilic substitution at the phenyl ring.
科研通智能强力驱动
Strongly Powered by AbleSci AI