Desmopressin Resistant Nocturnal Polyuria Secondary to Increased Nocturnal Osmotic Excretion

Nocturnal polyuria with high urinary osmolality in our patients with desmopressin resistant monosymptomatic nocturnal enuresis is related to abnormal increased osmotic excretion. This may be explained by their fluid and diet habits, eg daytime fluid restriction, and high protein and salt intake.