光热治疗
吲哚青绿
体内
纳米技术
材料科学
药物输送
肿瘤微环境
癌症
癌症研究
癌细胞
生物相容性
生物医学工程
医学
生物物理学
化学
内科学
病理
肿瘤细胞
有机化学
生物技术
生物
作者
Ke Jiang,L. Zhang,Quan Hu,Dan Yue,Jihao Zhang,X. Zhang,B. Li,Yuanjing Cui,Yu Yang,Guodong Qian
标识
DOI:10.1016/j.mtnano.2018.09.001
摘要
Indocyanine green (ICG), as the only U.S. Food and Drug Administration–approved near-infrared (NIR) clinical agent, has been considered as an ideal light absorber for laser-mediated photothermal therapy (PTT) in cancer treatment. However, the practical applications of ICG are severely hampered by its poor aqueous stability, rapid body clearance, and low cellular uptake. To overcome these limitations, we herein report the successful example of integrating ICG into a zeolitic imidazolate framework (ZIF-8) to fabricate a novel nanoscale [email protected] hybrid material. Through a simple one-pot synthesis method, a high loading content of 20.6% can be achieved in the resultant [email protected] The photostability and tumor accumulation of ICG are notably promoted due to the protection of the framework, leading to enhanced photothermal conversion efficiency. Furthermore, we also discover, for the first time, that the pH-triggered release of large amount of Zn2+ from ZIF-8 in tumor acidic microenvironment also significantly contributes to targeted killing of cancer cells. As a result of the combined PTT and chemotherapy, [email protected] exhibits greatly improved diagnostic efficacy for both in vitro and in vivo cancer therapy, leading to 91% tumor eradication in all the mice treated with [email protected] and NIR irradiation. Hematoxylin and eosin (H&E)–stained slices show that no noticeable tissue damage is observed in major organs, indicating the safety of [email protected]
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