间充质干细胞
干细胞
股骨头
医学
骨髓
脂肪组织
临床试验
翻译(生物学)
生物信息学
骨细胞
骨髓干细胞
病理
癌症研究
体外
生物
基因
内科学
细胞生物学
外科
成骨细胞
信使核糖核酸
遗传学
作者
Yi Wang,Xibo Ma,Wei Chai,Jie Tian
摘要
The last couple of decades have seen brilliant progress in stem cell therapies, including native, genetically modified, and engineered stem cells, for osteonecrosis of the femoral head (ONFH). In vitro studies evaluate the effect of endogenous or exogenous factor or gene regulation on osteogenic phenotype maintenance and/or differentiation towards osteogenic lineage. The preclinical and clinical outcomes accelerate the clinical translation. Bone marrow mesenchymal stem cells and adipose-derived stem cells have demonstrated better effects in the treatment of femoral head necrosis. Various materials have been used widely in the ONFH treatment in both preclinical and clinical trials. In a word, in vivo and multiscale efforts are expected to overcome obstacles in the approaches for treating ONFH and provide clinical relevance and commercial strategies in the future. Therefore, we will discuss the above aspects in this paper and present our opinions.
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