酮洛芬
布洛芬
对映体
氟比洛芬
化学
金属有机骨架
对映选择合成
吸附
己烷
外消旋混合物
对映体过量
色谱法
有机化学
催化作用
药理学
医学
作者
Shakir Ullah,Uzma Yunus,Moazzam H. Bhatti,Peter D. Southon,Kiran Iqbal,Sadia Zaidi
标识
DOI:10.1002/slct.201802086
摘要
Abstract Three new homochiral MOFs (MOF‐808‐S‐ibuprofen, MOF‐808‐S‐proline and MOF‐808‐S‐lactic acid) were synthesized via the post synthetic modification of achiral MOF‐808 and were characterized by various analytical tools. The new homochiral MOFs (HCMOFs) were examined for the enantioselective adsorption of racemic drugs. The n‐hexane solution of racemic ibuprofen, ketoprofen and flurbiprofen were allowed to adsorb in the chiral channels of the HCMOFs. The drugs were desorbed form porous HCMOFs and analysed by chiral HPLC. MOF‐808‐S‐ibuprofen selectively adsorbed R ‐ibuprofen and R ‐ketoprofen with enantiomeric excess ( ee ) of 50 and 56% respectively.
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