应力颗粒
颗粒（地质）
细胞生物学
肝纤维化
纤维化
信使核糖核酸
脂滴
自噬
细胞内
生物
肝病
化学
RNA解旋酶A
肝星状细胞
花生四烯酸
致密颗粒
疾病
细胞质
酶
病态的
癌症研究
高尔基体
生物化学
核糖核酸
肝细胞
细胞器
特发性肺纤维化
肝硬化
细胞
肌成纤维细胞
基质金属蛋白酶
分子生物学
肺
作者
Yunhui Li,Ting Lei,Wen Nie,Mingrui Ma,Wei Zhao,Ye Zhou,Yanfang Liu,Minjun Wang,Kaiwei Jia,Shanrong Liu,Yuanyuan Wang,Yiwen Fan,Long Chen,Xing He,J. H. Yuan,Xuetao Cao,Jin Hou
标识
DOI：10.1016/j.cmet.2025.12.015
摘要
C)-modified mRNA of pro-fibrotic hepatokine tissue inhibitor of metalloproteinase 2 (Timp2) and its reader Y-box binding protein 1 (YBX1) were recruited into LIGs, thereby inhibiting Timp2 mRNA translation and consequently feedback suppressing liver fibrosis. Moreover, LIGs were identified in human MASLD livers and exhibited reverse correlation with fibrosis progression. Therefore, we identified a new granule in steatotic hepatocytes and elucidated its role in restraining liver fibrosis.
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(2025-6-4)
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