Molecular Engineering of Strong Electron‐Deficient Acceptor for Constructing D‐A Conjugated Polymers in NIR‐II Photothermal Therapy

(dark conditions) and >80% apoptosis induction upon laser treatment. In vivo, NP1-mediated PTT achieved complete tumor regression (56.4°C peak temperature) without systemic toxicity, while photoacoustic imaging provided clear tumor delineation. This work establishes a robust molecular design paradigm for NIR-II-absorbing conjugated polymers, advancing safe and effective theranostic agents for deep-tissue cancer treatment.