Changes of T cell subsets and related cytokines in children with measles

Objective To investigate the immunization status in children with measles rash. Methods Flow cytometry and ELISA was employed to investigate the changes of CD4+T,CD8+T,TL-2,TL-4,TL-6,TL-10 in early rash and after rash,and then compared with those in healthy children. Results CD4+T decreased,while CD8+T increased in early rash,and returned to normal after rash. TL-2 increased significantly in early rash(P0.01) ,and decreased after the rash,but still maintained high level(P0.05) . TL-4,TL-6 was low and increased immediately after the rash(P0.05) ,and TL-10 always maintained a high level in early rash and after rash(P0.05) . All the changes had no relation with gender and age,but in younger patients,the younger the patients,the greater CD4+T declined may be in the early rash. Conclusion There is the brief reversible immunosuppression in children with measles,TH1 dominates the early while TH2 plays an important role after rash. TL-10 plays an important regulatory role in children with measles immunization. Immune disorders may be more serious in younger patients