[The protective effects of IPC on isolated myocardial ischemia/reperfusion injury in rats].

AIM: To investigate the protective effects and mechanism of IPC on myocardial ischemia/reperfusion injury. METHODS: Effects of IPC on arrhythmia and coronary blood flow and the release of AST, CPK, LDH, SOD and LFO at different time after ischemia/reperfusion injury in rat Langendorff hearts were studied. RESULTS: IPC decreased the release of AST, CPK and LDH and increased myocardial SOD activity and decreased LPO level. IPC also inhibited ischemia/reperfusion arrhythmias and increased coronary blood flow. CONCLUSION: The results showed that IPC had well protective effects on myocardial ischemia/reperfusion injury.