Effects of antipsychotic chlorderazin,clozapine and risperidone on blood glucose

Objective:To understand the effects of antipsychotic,chlorderazin,clozapine and risperidone on blood glucose in patients with schizophrenia.Methods: Eighty eight patients first onset with schizophrenia were randomly divided into three groups,each group treated with chlorderazin,clozapine and Risperidone respectively for 8 weeks.The blood glucose,using Rayto-200c automatic biochemistry analyzer,was tested before treatment, at 4 and 8 weeks management.Results:The blood glucose level was higher in group clozapine than other two groups(P0.01),but no changes in group chlorderazin and Risperidone before and after drug treatment(P0.05).Conclusion: Clozapine can produce metabolic disorder of blood glucose.We should monitor it when initiate clozapine for patients.