A Comparison Analysis between the Expressions of Serum MiR-200a and AFP in Liver Cirrhosis and Liver Cancer Patients

Objective:This study aimed to analyze the expression levels of serum microRNA-200a(miR-200a) and AFP in liver cirrhosis and liver cancer patients,and to explore whether miR-200a could be a novel biomarker of liver cancer.Methods: Patients with normal liver,liver cirrhosis and liver cancer in clinic were included in this study.Blood samples of the patients were collected for analysis.Real time quantitative PCR technique was used to measure the expression level of serum miR-200a.The AFP expression was got from clinical data.Results: Comparing with normal liver patients,miR-200a presented lower expressions in liver cirrhosis patients and liver cancer patients(P0.05),while AFP presented higher expressions only in liver cancer patients(P0.05).Conclusion: Data indicated that MiR-200a played an important role in liver cancer development and had diagnostic value for indicating liver cirrhosis and liver cancer.