Objective: To observe the effect of nimodipine on postoperational patients with hypertensive intracerebral hemorrhage. Methods: 60 of patients were divided into group of control and group of nimodipine treatment, all patients were observed by clinical curative effect.Nimodipine was performed with nimodipine group within 6h after operation and last 14d. Assessment of clinical curative effect were used by blind analysis. Results: After treatment, there were mild and moderate disability in 18 cases, severe disability in 6 cases, vegetative state in 2 and death in 3 cases in nimodipine treatment group. Good recover rate was 83.33% in nimodipine treatment group. The clinical curative effect in treatment group were significantly better than in the control group. Conclusion: Nimodipine is safe and effective for preventing the postoperational patients with hypertensive intracerebral hemorrhage from brain damage,reducing the mortality and improving the survival rate and life quality.