Effect of Fei-te-ling VI on Bleomycin-induced Mice Pulmonary Fibrosis and Its Mechanisms

Objective To investigate the protection of Fei-te-ling Ⅵ(FTL Ⅳ) on bleomycin-induced mice pulmonary fibrosis.Methods Models were reproduced by intratracheal injection of bleomycin.After continully administrated of 28 d,model animals in each group were sacrificed,and lungs were havested for investigating the changes of lung index,pathomorphological changes by HE staining.The extent of plumonary alveolitis and fibrosis were evaluated by Szaopiel's method;SOD,MDA,HYP and T-AOC in lung tissue were analyzed by biochemical detection.Results Contrasting with the model group,FTL Ⅵ could significantly increase weights of mice,depress lung index and the extent of lung alveolitis and fibrosis,FTL Ⅵ could significantly increase SOD,T-AOC and reduce the content of HYP,MDA in lung tissue(P0.05 or 0.01).Conclusion FTL Ⅵ might have some protective effects on bleomycin-induced mice pulmonary fibrosis.