Synthesis of Ferrocenyl Substituted Dihydropyridine Compounds

Objective To introduce ferrocenyl group into the dihydropyridine ring by using conventional heating under optimized reaction conditions. Methods To evaluate the influences of reaction conditions such as different nitrogen resources including ammonium bicarbonate,urea and ammonium acetate,different reaction times and reaction solvents. Results The target was obtained with the yield of 79.3% by using ammonium acetate as nitrogen source under around 57 ℃ for 90 min in the absence of solvent. Conclusion Conventional heating was used in a solvent free one-pot reaction to synthesize ferrocenyl-dihydropyridine derivatives. Compared with previous synthetic methods,this procedure can give higher yield with avoiding by-products,less pollution,and meets the requirements of green chemistry so that it is more suitable in industrial applications.