Objective:To observe clinical efficacy of Placenta Hominis extract,Human Placental Histosolution and Human Placenta Lipopolysaccharide in treating with childhood vitiligo.Methods:To evaluate efficacy of Placenta Hominis extract,Human Placental Histosolution and Human Placenta Lipopolysaccharide combined infrared radiation treatment of childhood vitiligo 20 min twice a day,and the same times apply drugs 5min intervals to lesion.Results:The effective rate of Placenta Hominis extract,Human Placental Histosolution and Human Placenta Lipopolysaccharide was respectively 78.50%,47.06% and 57.14%,the markedly effective rate was respectively 38.32%,23.53% and 38.10%.After treatment,there were statistically significant differences between three drugs as regards to the efficiency(P0.05).The effective rate and markedly effective rate of Placenta Hominis extract were higher than others.In addition,the effective rate of Placenta Hominis extract as high as 89.66% for the scalp and significant differences were observed between scalp and other part(P0.05).Conclusions:Three drugs combined infrared radiation has a good effect on childhood vitiligo,and the efficiency of Placenta Hominis extract is superior to Human Placental Histosolution and Human Placenta Lipopolysaccharide.