Perioperative artificial nutrition in malnourished gastroin-testinal cancer patients

AIM: To investigate the potential role of perioperative nutrition in reducing complications and mortality in malnourished gastrointestinal cancer patients. METHODS:Four hundred and sixty-eight elective moderately or severely malnourished surgical patients with gastric or colorectal cancers defined by the subjective global assessment (SGA) were randomly assigned to 7 d preoperative and 7 d postoperative parenteral or enteral nutrition vs a simple control group.The nutrition regimen included 24.6±5.2kcal /kg per d non-protein and 0.23±0.04g nitrogen /kg per d.Control patients did not receive preoperative nutrition but received 600±100 kcal non-protein plus or not plus 62 ± 16 g crystalline amino acids postoperatively. RESULTS:Complications occurred in 18.3% of the patients receiving nutrition and in 33.5% of the control patients (P = 0.012).Fourteen patients died in the control group and 5 in those receiving nutrition.There were significant differences in the mortality between the two groups (2.1% vs 6.0%, P = 0.003).The total length of hospitalization and postoperative stay of control patients were significantly longer (29 vs 22 d, P = 0.014) than those of the studied patients (23 vs 12 d，P = 0.000). CONCLUSION:Perioperative nutrition support is beneficial for moderately or severely malnourished gastrointestinal cancer patients and can reduce surgical complications and mortality.