化学
齿合度
催化作用
卤化物
钯
反应性(心理学)
选择性
螯合作用
药物化学
组合化学
芳基
有机化学
金属
替代医学
病理
烷基
医学
作者
Kevin W. Anderson,Rachel E. Tundel,Takashi Ikawa,Ryan A. Altman,Stephen L. Buchwald
标识
DOI:10.1002/anie.200601612
摘要
A good alternative: Highly reactive catalysts based on palladium and dialkylbiarylphosphino ligands provide unprecedented reactivity and selectivity in CN bond-forming processes. The bulky monophosphine catalyst system Pd/1 was effective for the reaction of aryl/heteroaryl halides bearing primary amides and 2-aminoheterocycles (see scheme; dba=dibenzylideneacetone, R=CONH2, NH2), thus showing that monodentate phosphines are viable alternatives to, and sometimes superior to, chelating ligands.
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