肌萎缩
医学
概念化
老年学
制度化
心理干预
特质
精神科
计算机科学
解剖
人工智能
程序设计语言
作者
Francesco Landi,Riccardo Calvani,Matteo Cesari,Matteo Tosato,Anna Maria Martone,Roberto Bernabei,Graziano Onder,Emanuele Marzetti
标识
DOI:10.1016/j.cger.2015.04.005
摘要
Physical function decreases with aging, which may result in adverse outcomes (eg, disability, loss of independence, institutionalization, death). Physical function impairment is a common trait of frailty and sarcopenia. These two conditions, albeit highly common, have not yet received a unique operational definition, which has impeded their implementation in standard practice. Here, we introduce a conceptual model in which sarcopenia is proposed as the biological substrate and the pathway whereby the consequences of physical frailty develop. This conceptualization may open new venues for the design of interventions against physical frailty and promote the translation of findings to the clinical arena.
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