ALLICIN PREVENTS MPTP‐INDUCED MOTOR DYSFUNCTION AND BIOCHEMICAL ABNORMALITIES IN WISTAR RATS

Abstract Background Parkinson’s disease (PD) is an age‐related progressive neurodegenerative disorder, characterized by loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the brain. Dopaminergic degeneration involves the number of mechanisms such as oxidative stress and neuroinflammation. Allicin has been reported to exert various anti‐oxidative and anti‐inflammatory activities in in‐vitro and in‐vivo studies. Therefore, in the present study, we have investigated neuroprotective effect of allicin against MPTP induced Parkinson’s disease in rats. Method Repeated intranigral infusion of MPTP at day 1 st , 4 th , and 7 th produced significantly loss in body weight, locomotor activity, motor coordination, antioxidant defense enzymes (reduced glutathione) and significantly increase oxidative stress markers (lipid peroxidation and nitrite level) in the striatum. MPTP treatment also increased pro‐inflammatory cytokines (TNF‐α, IL‐6, and IL‐1β) level and decreased neurotransmitter level in the striatum. Allicin (5, 10 and 20mg/kg/day i.p.) treatment from day 8 th to 21 st significant reversed the behavioral, antioxidant defense enzymes, oxidative stress marker and pro‐inflammatory cytokines in MPTP infused rats. Result Allicin (5, 10 and 20mg/kg/day i.p.) treatment from day 8 th to 21 st significant reversed the behavioral, antioxidant defense enzymes, oxidative stress marker and pro‐inflammatory cytokines in MPTP infused rats. Conclusion The consequences of particular study suggest the beneficial effects of allicin in PD.