医学
血流动力学
不利影响
心室辅助装置
心脏病学
心力衰竭
血栓形成
连续流动
人工心脏
冲程(发动机)
目的地治疗
重症监护医学
内科学
机械工程
物理
机械
工程类
作者
Jonathan Grinstein,Mark N. Belkin,S. Kalantari,Kevin Bourque,Christopher T. Salerno,Sean Pinney
标识
DOI:10.1016/j.jacc.2023.04.045
摘要
Left ventricular assist devices (LVADs) provide lifesaving therapy for patients with advanced heart failure. The recognition of pump thrombosis, stroke, and nonsurgical bleeding as hemocompatibility-related adverse events (HRAEs) led to pump design improvements and reduced adverse event rates. However, continuous flow can predispose patients to right-sided heart failure (RHF) and aortic insufficiency (AI), especially as patients live longer with their device. Given the hemodynamic contributions to AI and RHF, these comorbidities can be classified as hemodynamic-related events (HDREs). Hemodynamic-driven events are time dependent and often manifest later than HRAEs. This review examines the emerging strategies to mitigate HDREs, with a focus on defining best practices for AI and RHF. As we head into the next generation of LVAD technology, it is important to differentiate HDREs from HRAEs so that we can continue to advance the field and improve the true durability of the pump-patient continuum.
科研通智能强力驱动
Strongly Powered by AbleSci AI