Validation of the Informant Quick Dementia Rating System (QDRS) among Older Adults in Singapore

临床痴呆评级 痴呆 克朗巴赫阿尔法 临床试验 金标准(测试) 认知 医学 可靠性(半导体) 评定量表 认知障碍 心理学 临床心理学 老年学 心理测量学 精神科 内科学 发展心理学 物理 功率(物理) 疾病 量子力学
作者
Ting Pang,Eddie Chong,Zi Xuen Wong,Kimberly Ann Chew,Narayanaswamy Venketasubramanian,Christopher Chen,Xin Xu
出处
期刊:Journal of Alzheimer's Disease [IOS Press]
卷期号:89 (4): 1323-1330 被引量:9
标识
DOI:10.3233/jad-220520
摘要

Background: The Quick Dementia Rating System (QDRS) is a brief and rapid tool that can be administered by an informant without the need for a trained assessor. Objective: Our objective was to examine the validity, reliability, and cost-effectiveness of the informant QDRS in a Singapore memory clinic sample. Methods: We assessed a total of 177 older adults, among whom, 32 had no cognitive impairment (NCI), 61 had mild cognitive impairment (MCI), and 84 had dementia. Elderly underwent 1) the informant QDRS, 2) the Clinical Dementia Rating (CDR) as the gold standard diagnosis, 3) the Mini-Mental State Examination (MMSE), and 4) the Ascertain Dementia 8 (AD8) as comparisons to the QDRS. The extent to which the QDRS may reduce the recruitment cost (time) of clinical trials was also calculated. Results: The QDRS had excellent internal consistency (Cronbach alpha = 0.939). It correlated highly with the CDR-global (R = 0.897), CDR Sum-of-Boxes (R = 0.915), MMSE (R = –0.848), and the AD8 (R = 0.747), showing good concurrent validity. With an optimal cut-off of 1.5 for MCI (sensitivity 85.2%, specificity 96.3%) and 6 for dementia (sensitivity 90.1%, specificity 89.2%), the QDRS achieved a higher overall accuracy of 85.0%, as compared to MMSE (71.2%) and AD8 (73.4%). A simulated clinical trial recruitment scenario demonstrated that pre-screening with the QDRS followed by a confirmatory CDR would reduce the time needed to identify NCI subjects by 23.3% and MCI subjects by 75.3%. Conclusion: The QDRS is a reliable cognitive impairment screening tool which is suitable for informant-administration, especially for identification of MCI.
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