室管膜细胞
生物
神经干细胞
干细胞
谱系(遗传)
中枢神经系统
再生(生物学)
细胞生物学
神经科学
细胞
电池类型
脑脊液
脊髓
前体细胞
遗传学
基因
作者
Bruno Frederico,Isaura Martins,Diana Chapela,Francesca Gasparrini,Probir Chakravarty,Tobias Ackels,Cécile Piot,Bruna Almeida,Joana Carvalho,Alessandro Ciccarelli,Christopher J. Peddie,Neil C. Rogers,James Briscoe,François Guillemot,Andreas Schaefer,Leonor Saúde,Caetano Reis e Sousa
标识
DOI:10.1016/j.devcel.2022.07.012
摘要
Cells with latent stem ability can contribute to mammalian tissue regeneration after damage. Whether the central nervous system (CNS) harbors such cells remains controversial. Here, we report that DNGR-1 lineage tracing in mice identifies an ependymal cell subset, wherein resides latent regenerative potential. We demonstrate that DNGR-1-lineage-traced ependymal cells arise early in embryogenesis (E11.5) and subsequently spread across the lining of cerebrospinal fluid (CSF)-filled compartments to form a contiguous sheet from the brain to the end of the spinal cord. In the steady state, these DNGR-1-traced cells are quiescent, committed to their ependymal cell fate, and do not contribute to neuronal or glial lineages. However, trans-differentiation can be induced in adult mice by CNS injury or in vitro by culture with suitable factors. Our findings highlight previously unappreciated ependymal cell heterogeneity and identify across the entire CNS an ependymal cell subset wherein resides damage-responsive neural stem cell potential.
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