Long-term effect of pulmonary rehabilitation in idiopathic pulmonary fibrosis: a randomised controlled trial

医学 肺康复 任天堂 康复 物理疗法 随机对照试验 特发性肺纤维化 肺功能测试 内科学
作者
Kensuke Kataoka,Osamu Nishiyama,Takashi Ogura,Yoshihiro Mori,Ryo Kozu,Shinichi Arizono,Tohru Tsuda,Hiromi Tomioka,Keisuke Tomii,Koji Sakamoto,Hiroshi Ishimoto,Michiko Kagajo,Hiroyuki Ito,Kazuya Ichikado,Hajime Sasano,Seiichirou Eda,Machiko Arita,Yasuhiro Gotô,Osamu Hataji,Satoshi Fuke
出处
期刊:Thorax [BMJ]
卷期号:78 (8): 784-791 被引量:32
标识
DOI:10.1136/thorax-2022-219792
摘要

Background Idiopathic pulmonary fibrosis (IPF) is characterised by worsening dyspnoea and exercise intolerance. Research question Does a long-term pulmonary rehabilitation improve exercise tolerance in patients with IPF treated with standard antifibrotic drugs, which are expected to reduce disease progression? Methods This open-label randomised controlled trial was performed at 19 institutions. Stable patients receiving nintedanib were randomised into pulmonary rehabilitation and control groups (1:1). The pulmonary rehabilitation group underwent initial rehabilitation which included twice-weekly sessions of monitored exercise training for 12 weeks, followed by an at-home rehabilitation programme for 40 weeks. The control group received usual care only, without pulmonary rehabilitation. Both groups continued to receive nintedanib. The primary and main secondary outcomes were change in 6 min walking distance (6MWD) and change in endurance time (using cycle ergometry) at week 52. Results Eighty-eight patients were randomised into pulmonary rehabilitation (n=45) and control (n=43) groups. Changes in 6MWD were −33 m (95% CI −65 to −1) and −53 m (95% CI −86 to −21) in the pulmonary rehabilitation and control groups, respectively, with no statistically significant difference (mean difference, 21 m (95% CI −25 to 66), p=0.38). Changes in endurance time were significantly better in the pulmonary rehabilitation (64 s, 95% CI −42.3 to 171)) than in the control (−123 s (95% CI −232 to −13)) group (mean difference, 187 s (95% CI 34 to 153), p=0.019). Interpretation Although pulmonary rehabilitation in patients taking nintedanib did not improve 6MWD in the long term, it led to prolonged improvement in endurance time. Trial registration number UMIN000026376.
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