二甲双胍
医学
药品
作用机理
2型糖尿病
糖尿病
动作(物理)
机制(生物学)
药理学
内分泌学
生物
生物化学
量子力学
认识论
体外
哲学
物理
作者
Emma Barroso,Marta Montori-Grau,Walter Wahli,Xavier Palomer,Manuel Vázquez‐Carrera
标识
DOI:10.1016/j.tips.2023.04.004
摘要
Metformin is the most prescribed drug for the treatment of type 2 diabetes mellitus (T2DM), but its mechanism of action has not yet been completely elucidated. Classically, the liver has been considered the major site of action of metformin. However, over the past few years, advances have unveiled the gut as an additional important target of metformin, which contributes to its glucose-lowering effect through new mechanisms of action. A better understanding of the mechanistic details of metformin action in the gut and the liver and its relevance in patients remains the challenge of present and future research and may impact drug development for the treatment of T2DM. Here, we offer a critical analysis of the current status of metformin-driven multiorgan glucose-lowering effects.
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